House and his team treat a patient who had his brain split in half, now it seems like one side of his brain is causing some health/behavioral issues. House plays games with Cuddy over the night he detoxed, and those events will cause major changes. Cameron and Chase come to a decision.
After House's medical license is reinstated, he reclaims his role as Head of Diagnostics in time to treat Hank Hardwick, an adult film star admitted to Princeton Plainsboro for pulsating eye pain. Meanwhile, Cuddy is reminded that the hospial is not conducive to healthy personal relationships, and House angles to form a dream team.
House and the team take on the case of James Sidas, an exceptionally brilliant physicist and author who traded his successful career for a job as a courier. For the ailing patient, intelligence is a miserable burden that has prompted depression and addiction, and this, coupled with his myriad unusual symptoms, nearly stumps the team. Meanwhile, the doctors at Princeton Plainboro wrestle with strained personal relationships.
Physics student and his father, Artie, bring in the kid's lover Abby Nash, who nearly suffocated in foam during a planetarium lecture. The team eliminates everything except an allergy to something in her body. House presses Wilson to buy furniture as a way to express his personality.
House and the team take on the case of a woman Julia, who is in an open marriage and becomes ill during a date with her on-the-side boyfriend. As perplexing as the case is, Julia's happy and healthy, yet polygamous relationship is equally baffling to the team. Meanwhile, House tests Wilson's relationship with Sam.
Science and faith are called into question when a patient is admitted to the hospital following his reenactment of the Crucifixion. The patient, Ramon Silva, refuses to undergo the prescribed treatment, and the team learns that after his daughter's cancer was cured, he pledged an oath of self-sacrifice to God. With little time to save Ramon's life, the team struggles to understand his reasoning and seemingly extreme religious convictions, but eventually learn that faith is not an argument. Meanwhile, Taub questions his wife Rachel about her relationship with an ...
When a man puts his life on the line to save a stranger who fell onto the subway tracks, he emerges from the dramatic scene miraculously unscathed but then suddenly collapses. Both the hospital and the town become captivated by the man's selfless deed, but as the team works to diagnose his symptoms, they discover that the hero's seemingly life-changing deed failed to break old habits. Meanwhile, House tries to avoid Cuddy's birthday dinner with her opinionated mother Arlene, and Taub draws unexpected attention when his face graces billboards advertising the hospital. ...
Cuddy's mother, Arlene, is admitted to Princeton Plansboro after complaining about unusual symptoms, but stubborn Arlene insists that House be removed from the case, forcing House to come up with non-conventional - and illegal - means to treat his patient. House instructs his team to follow his lead, and they discover details in Arlene's personal life that she kept secret from Cuddy and her sister Lucinda. Later, Cuddy places her trust in House to ensure that her mother receives the proper medical treatment, leading "by the book" medical student Masters to reevaluate ...
Well-known performance artist Afsoun Hamidi is admitted to the hospital, but when the team learns that her symptoms may have been self-inflicted as part of a documentary for her latest performance piece, they begin to question whether treatments are necessary and if they are unwittingly participating in the creation of a piece of her art. Meanwhile, a situation prompts House to do something that could change his relationship with Cuddy and Wilson permanently.
A teenage boy attempting to follow in his late father's footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Meanwhile, House looks for creative ways to remove his ankle monitor so that he can attend a boxing match in Atlantic City, and he treats a patient who is convinced he is suffering from diabetes. Also, Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.
House überlegt intensiv, wie er verhindern kann, dass er vor Wilsons Tod ins Gefängnis muss. Zuerst überredet er Foreman zu einer Falschaussage. Doch als diesem die Sache zu heiß wird, macht Foreman einen Rückzieher. Dann versucht er sein Glück bei Wilson, aber auch der hat keine Lust auf einen Meineid. Doch zufällig bekommt House einen neuen Patienten, der ebenfalls dem Tod geweiht ist. Der erklärt sich bereit, House zu helfen – allerdings nur unter bestimmten Bedingungen. Der unberechenbare Arzt soll den Mann auf seinem letzten Weg begleiten. Das Ganze soll in einem Lagerhaus passieren. Der passenden Atmosphäre geschuldet, brennt bei Houses Ankunft bereits ein Feuer, das jedoch langsam auf das ganze Lagerhaus übergreift. In der Zwischenzeit sind Foreman und Wilson auf der Suche nach House – beide vermuten Schlimmes. Während House sich der tödlichen Lage ergibt, erscheinen ihm einige Personen, die ihn auf seinem Weg durch das Princeton Plainsboro begleitet haben. Aber keiner der geisterhaften Erscheinungen kann ihn dazu überreden, das brennende Haus zu verlassen. In der Zwischenzeit haben Foreman und Wilson endlich Houses Aufenthaltsort herausgefunden. Als sie ihn in dem Gebäude entdecken, sehen sie wie die brennende Decke über House zusammenstürzt. Doch ist House tatsächlich tot?