House treats a Black presidential candidate, whom House is convinced has AIDS, but the Senator's passion convinces him otherwise. Also, Vogler forces House to give a speech endorsing a new drug from Vogler's company, but House has plans of his own.
House's ex Stacy Warner asks him to treat her husband. House takes over a diagnostics class for a day and presents the class with three case studies of leg pain. As House tells his story and the class gradually fills up with listeners, the class learns a lot about how to be better doctors, and Chase, Foreman and Cameron learn some important details of House's past.
Richard, a husband and father living with brain cancer, drives his wheelchair into a pool at a family BBQ. Everyone but his son think that it was suicide from the pain but House will stop at nothing to figure out his true ailment.
Clancy, a 7 year old boy, who believes he is being tortured by aliens comes to the hospital because of rectal bleeding. When House, who thinks he did not solve his last case and it's affecting him physically, finds a metal object in his neck where Clancy claims a chip has been planted and when a cell with different DNA is found, the team has to give his alien theory more credit. But House's humiliation from his last case and worsening leg pain cause him to back out, forcing Cuddy, who lied to House about curing his last patient, to rethink her decision to withhold the information.
Ezra Powell, a renowned pioneer in the field of medical research, collapses in his lab. House is struggling after the ketamine treatment wore off and doesn't want to talk about it. When the team put Ezra through rigorous diagnostic tests and don't come up with anything conclusive Ezra demands the team to help him end his life. Now the team goes through twists and turns of the moral dilemma of ignoring his wishes or to assist in his suicide and abide by Ezra's wishes.
A ten-year-old boy begins screaming in pain, but nobody knows why, because he is autistic and cannot explain. House refuses to use his office. Cuddy does not know why, because he is House and will not explain.
Wilson presents the deal to House and then convinces Cuddy to back him up, meanwhile the team is flummoxed by a patient's condition and various members keep seeking out House for his opinion even though he may not be prepared to assist.
House and Cuddy are flying back to the US from an international conference in Singapore. While en route a mysterious disease strikes one passenger and an epidemic unfolds, causing House to diagnose in midair since they have missed the halfway mark by passing the north pole. Back in Princeton, Wilson and House's lackeys have a confusing case of what is ailing a woman who came into the clinic and proceeded to have a seizure.
A young girl is ailed with diseases that usually strike people much older than her 6 years of age. But before House can diagnose her, her brother starts exhibiting the same symptoms she was admitted with. During all of this House gives Wilson tickets that a patient had given to him for a play. Ensuing a discussion on why men take women to plays. Wilson decides to take Cuddy and the tug of war with House for her affections begins, although Cuddy insists that she only went with Wilson as a friend.
Wilson is preparing his 14-year-old patient, Nick, for a bone marrow transplant when the donor, Nick's younger brother Matty, suddenly starts sneezing. Since Nick's immune system has been destroyed by the chemotherapy for his cancer, he cannot risk a marrow donation from Matty while Matty is ill. House decides that the fastest way to find out what's wrong with Matty is to make him worse. As the boys get sicker and sicker, House and his team race to cure Matty before both brothers die. Meanwhile, House battles Hector (his newly adopted dog) for supremacy and Foreman can't stop thinking about last week's mistake.
A 19-year-old college student, Addie, starts coughing up blood during karate class and ends up one of House's cases. Foreman hands in his resignation before treating the woman and refuses to explain why. Although her symptoms show no signs of it, House is convinced that an infection is causing Addie's bleeding. Her lungs start filling with fluid and House's team believes a toxin or cancer is to blame for Addie's illness but are unable to change House's mind. Addie continues to get worse and House wants to do an extremely risky life-or-death treatment in order to confirm his diagnosis; the team starts to ask whether House cares about making a diagnosis more than Addie's own life. Meanwhile, House becomes interested in Honey, a young, attractive nutritionist who brought her boyfriend to the clinic for treatment. He gets her to fill out an employment application (for Foreman's soon-to-be vacated position) and arranges to meet her again in a more casual situation.
House is forced to choose a new staff... and gathers 40 applicants to start narrowing down the field. Meanwhile, an Air Force pilot wants House to treat her secretly so she doesn't ruin her chances of becoming an astronaut.
Down to 10 candidates for his team, House splits them into 2 groups to diagnose a patient whose short lifespan has been made even shorter. Foreman leads his own team to diagnose a patient at his new workplace.
A victim of a mugging presents with neurological symptoms and begins to mirror the behaviors of his doctors. Foreman joins the new fellows in seeking a diagnosis; Cameron and Chase takes bets on who House will fire next.
Years after receiving body parts from an organ donor, five out of six recipients die within a few months, but not from organ rejection. House and the team race against time to figure out why before the final surviving recipient, a young woman who received the donor's cornea, mysteriously dies as well. House retains a comical private investigator to investigate patients, doctors, and his estranged friend, Wilson.
House tries every delaying tactic available when Wilson forces him to attend his father's funeral. Meanwhile, the team tries to find the cause of a young woman's abdominal pain and hemorrhage that occurred in China.
House takes on a case where the patient has unexplained blackouts, and his daughter may hold the key to the diagnosis. Meanwhile, Cuddy prepares for her new arrival until there are complications with the birth mother.
A person takes House, Thirteen and others as hostages. He's seen several doctors but none have found what ails him. As they work towards finding a solution, Thirteen makes decisions which leads her to think about her own condition.
An obese teenager collapses on stage, and the outcome will lead to a surprise for Cuddy. Wilson convinces House to be nice to his patients during the holidays. Foreman and Thirteen have issues when a trial patient drops from the program.
House's team resents being made complicit in a web of lies parents have told their son when he's brought in for treatment that may be related to his intersexuality. Meanwhile, no one's content that House is happy.
House is injured in a motorcycle accident. While recovering, he finds an accident victim suffering from a brain injury. House tries to prove the brain damage caused the accident, not vice versa, so he can treat the patient.
When all of House's efforts to rid himself of Amber fail, he turns to someone unexpected for assistance. Meanwhile, the team is left to fend for itself as they try to save a ballerina's life and career.
House and his team treat a patient who had his brain split in half, now it seems like one side of his brain is causing some health/behavioral issues. House plays games with Cuddy over the night he detoxed, and those events will cause major changes. Cameron and Chase come to a decision.
House returns home to Princeton where he continues to focus on his recovery, but surprises Cuddy with the news that he's making a big change in his life. Meanwhile, the team is unable to diagnose a loud-mouthed video game creator who posts each new symptom on the Internet and opts for treatments suggested by the online community rather than by the doctors, and Foreman angles for House's job, but the pressure to solve the case creates tension in his relationship with Thirteen.
When a controversial African politician falls ill, he is brought to Princeton Plainsboro for treatment. The team struggles with whether to help a merciless dictator being subpoenaed for crimes against humanity in his country. Meanwhile, Wilson tries to make peace with a feuding neighbor, but House's prying exacerbates the problem.
A wealthy businessman brings his teenage son, who is suffering from inexplicable stomach pains, to Princeton Plainsboro and insists on having Dr. House handle the case. The father of the patient believes the karmic penalty of his financial success is that he is victim to personal tragedy, and that the answer to his son's medical mystery lies in a reverse of fate rather than medical treatment. Meanwhile, Foreman and Chase prepare to present information on the Dibala case.
The team takes on the case of a reckless police detective who has a family history of sudden heart failure that killed his father, grandfather and great-grandfather all at age 40. Though House is not keen on diagnosing the patient without any detectable symptoms, the team, urged by Cameron, attempts to identify his condition so the detective can live without fear of dying young. Meanwhile, Chase is haunted by his actions in the Dibala case, and House confronts some ghosts of his own.
After House's medical license is reinstated, he reclaims his role as Head of Diagnostics in time to treat Hank Hardwick, an adult film star admitted to Princeton Plainsboro for pulsating eye pain. Meanwhile, Cuddy is reminded that the hospial is not conducive to healthy personal relationships, and House angles to form a dream team.
House and the team take on the case of James Sidas, an exceptionally brilliant physicist and author who traded his successful career for a job as a courier. For the ailing patient, intelligence is a miserable burden that has prompted depression and addiction, and this, coupled with his myriad unusual symptoms, nearly stumps the team. Meanwhile, the doctors at Princeton Plainboro wrestle with strained personal relationships.
When an old friend and former patient of Wilson's exhibits paralysis in his right arm, Wilson puts himself on the case. House wagers Wilson that the patient's symptoms are attributed to new cancer cells. Wilson accepts even though he is reluctant to believe the cancer has returned. With the help of the team, Wilson works to diagnose the patient more optimistic results, but when things take a turn for the worse, Wilson must address his inability to separate patient from friend. Meanwhile, Cuddy seeks advice in her search for real estate.
When drug dealer Mickey mysteriously collapses while negotiating a sale, his partner-in-crime, Eddie, accompanies him to Princeton Plainsboro for treatment. But with a major deal pending, Mickey is not forthcoming with the necessary personal information the team needs to treat him. As Mickey's condition worsens, the team resorts to old-fashioned detective work to solve the case. Meanwhile, House and Wilson compete for the affection of a new neighbor, and Chase, Thirteen and Taub attempt to play a practical joke on Foreman.
The team takes on the case of Valerie, an attractive female executive experiencing random episodes of excruciating pain. House agrees to take the case based on Valerie's looks, and while treating her, the men on the team are charmed by Valerie's beauty and personality, with Thirteen looking beyond the superficial to try to discover a link to her illness. Meanwhile, House uncharacteristically attempts to alleviate his conscience by reaching out to a former medical school colleague he wronged.
House and the team rush to treat an ailing college football star in time for the patient to compete in NFL tryouts. But when the patient experiences an onslaught of varied and unusual symptoms, the team has trouble reaching a consensus on how to effectively treat him in time. Meanwhile, Foreman's brother Marcus makes a surprise visit to the hospital.
During a day in the life of Princeton Plainsboro's Dean of Medicine, Dr. Lisa Cuddy, the inner workings of the hospital are seen through her eyes. This day proves to be especially trying as Cuddy wrestles with myriad hospital issues and staff disputes that test her perseverance and skills as an administrator, all while juggling issues in her personal life.
House and the team take on the case of an avid blogger admitted with sudden bruising and bleeding. From her hospital bed, the patient blogs about her symptoms, doctors and prospective diagnoses to her dedicated band of followers and solicits their advice on a course of treatment. Such openness leads the team to contemplate the value of privacy, especially after House and Wilson uncover secrets from one another's past. Meanwhile, Chase is coaxed into testing out the dating scene .
Physics student and his father, Artie, bring in the kid's lover Abby Nash, who nearly suffocated in foam during a planetarium lecture. The team eliminates everything except an allergy to something in her body. House presses Wilson to buy furniture as a way to express his personality.
When a newborn disappears from the nursery, Princeton Plainsboro goes on lockdown, preventing anyone from entering, leaving or moving within the hospital. While House and his team members are trapped in various parts of the building, new insights about the team's personal histories, relationships and regrets surface.
House and the team take on the case of Sir William, a "knight" in a closed-off community of men and women living according to the ideals of the High Renaissance. As the team searches the medieval village for environmental factors contributing to Sir William's rapidly deteriorating health, Thirteen and Sir William debate the acts that define honor and loyalty, especially in regard to the "queen" of the community, one of Sir William's most frequent visitors. Meanwhile, Wilson starts over with an ex.
House and the team take on the case of a woman Julia, who is in an open marriage and becomes ill during a date with her on-the-side boyfriend. As perplexing as the case is, Julia's happy and healthy, yet polygamous relationship is equally baffling to the team. Meanwhile, House tests Wilson's relationship with Sam.
During a session with Dr. Nolan, House recounts the case of a woman who arrives at the Princeton Plainsboro emergency room with an unexplained illness and no recollection of who she is. While trying to solve the mystery of the woman's illness, House must also help her piece together her identity.
House and Cuddy are exploring the ramifications of those feelings and attempting to make a real relationship work. Meanwhile, due to a colleague's illness, Princeton Plainsboro is left without a neurosurgeon on site, threatening the hospital's accreditation as a Level 1 Trauma Center. As the team attempts treatment to get their sick colleague back to work, they discover there is more to the illness than they originally suspected and turn to House for direction. Instead, House remains elusive, leaving the team on its own.
When Della, a seemingly healthy and active 14-year-old, suddenly collapses during a skateboarding exhibition, House and his team struggle to diagnose her condition and reassure her parents who already have to cope with their son's terminal illness. After her body rejects a donor lung, and with time running out to save her life, Della's family is left with little hope of securing a new donor and faced with a seemingly impossible decision regarding the fate of both children. Meanwhile, House tries to appease an elderly father and his son at the clinic, and House and ...
When Alice, the author of a popular children's book series, inexplicably suffers from a seizure moments before an attempt to take her own life, the Princeton Plansboro team faces the challenges of evaluating both her underlying medical conditions, as well as her unstable psychological state. Unable to diagnose Alice, House becomes particularly motivated, as he's a fan of her books, and is convinced that the key to unlocking the mysteries of Alice's condition lies in the pages of her most recent novel. Meanwhile, House takes Cuddy on a double date with Wilson and his ...
When a patient named Margaret McPherson is admitted to Princeton Plainsboro after suffering severe and uncontrollable vomiting, House and the team make unexpected discoveries about her identity as they assess her symptoms. When the symptoms don't improve, the team looks to the patient's medical history to unearth more about her past. Meanwhile, House gives Chase's new hire a cold welcome, and a visit from House's massage therapist forces House and Cuddy to confront the reservations in their relationship.
After a newborn experiences inexplicable breathing problems and liver failure, House and the team look at the baby's mother, Abbey's, own medical history for possible clues. When the team makes a discovery about her newborn's health, Abbey is presented with a difficult decision that could potentially affect both her baby's health and her own. Meanwhile, following Cuddy's directive, House challenges Foreman and Taub to hire a female doctor to join the team. When Cuddy asks House to babysit her daughter, both House and Wilson learn a few hard lessons in parenting.
It's election season, and in the midst of a tight campaign, an incumbent New Jersey senator's campaign manager falls ill with liver failure and temporary paralysis. Cuddy pushes House to add a female doctor to his team by hiring brilliant third-year medical student Martha Masters in Thirteen's absence. House and the team are wary of the young doctor's lack of experience and medical perspective, but are forced to give their new by-the-book teammate a chance to prove herself. After the campaigning senator makes a surprising announcement, House and the team look to the ...
After a 200-year-old medicine jar found on an off-shore shipwreck shatters in a teenage girl's palm, she is admitted to Princeton Plainsboro for symptoms closely linked to smallpox. When the Center for Disease Control's Dr. Dave Broda institutes a lockdown on the hospital and suspends House's team's ability to diagnose, Masters grows suspicious of Broda's motives and becomes convinced that the patient is suffering from a different disease. The girl's father soon experiences similar symptoms, and House is forced to make a precarious decision that puts his own life in ...
Science and faith are called into question when a patient is admitted to the hospital following his reenactment of the Crucifixion. The patient, Ramon Silva, refuses to undergo the prescribed treatment, and the team learns that after his daughter's cancer was cured, he pledged an oath of self-sacrifice to God. With little time to save Ramon's life, the team struggles to understand his reasoning and seemingly extreme religious convictions, but eventually learn that faith is not an argument. Meanwhile, Taub questions his wife Rachel about her relationship with an ...
When a man puts his life on the line to save a stranger who fell onto the subway tracks, he emerges from the dramatic scene miraculously unscathed but then suddenly collapses. Both the hospital and the town become captivated by the man's selfless deed, but as the team works to diagnose his symptoms, they discover that the hero's seemingly life-changing deed failed to break old habits. Meanwhile, House tries to avoid Cuddy's birthday dinner with her opinionated mother Arlene, and Taub draws unexpected attention when his face graces billboards advertising the hospital. ...
A teenage military trainee at a juvenile offender training camp suffers peculiar symptoms after enduring an intense training course, and mysteriously, his drill sergeant is soon admitted for similar symptoms. Unable to track down the cause of the shared illness, the team searches for clues in the trainee's family medical history, and Masters and House reveal a unique bond between the sergeant and trainee. Meanwhile, when an indecent photo of Chase is posted on a social-networking site following three different romantic encounters, Chase is determined to find out which...
Cuddy's mother, Arlene, is admitted to Princeton Plansboro after complaining about unusual symptoms, but stubborn Arlene insists that House be removed from the case, forcing House to come up with non-conventional - and illegal - means to treat his patient. House instructs his team to follow his lead, and they discover details in Arlene's personal life that she kept secret from Cuddy and her sister Lucinda. Later, Cuddy places her trust in House to ensure that her mother receives the proper medical treatment, leading "by the book" medical student Masters to reevaluate ...
When a waitress with a perfect memory suffers temporary paralysis, her older sister visits her in the hospital, which triggers high stress levels and even more health complications. The patient's sharp memory proves detrimental when a grudge she's been holding against her sibling gets in the way of receiving proper medical treatment, and Masters discovers that patching a broken sisterhood may prove to be more complex than diagnosing the patient. Meanwhile, Foreman volunteers to help Taub prepare for a medical examination, and House, determined to help Wilson get back ...
House participates in a school's Career Day and breaks a few rules by sharing explicit medical stories. Waiting outside the principal's office, he meets two fifth-grade students who assess House's relationship woes and try to help him understand how his selfish antics get in the way of showing Cuddy how he really feels.
A patient is admitted after breaking out in a severe rash triggered by caustic chemical exposure at his blue-collar job. As the team treats him, they discover that he has led his wife to believe that he is still maintaining his once-lucrative real estate career. Meanwhile, Cuddy is honored with an award and needs House to be at the charity event for support, but his attendance is threatened when his patient's battle to survive forces him to question his practice and his own happiness. Also, Chase and Masters teach each other a lesson in forging meaningful personal and...
Tension reaches new heights when Cuddy faces sobering news that propels her to reevaluate her priorities. While House is distracted by his concern for Cuddy's well-being, the team treats a teenage patient whose worsening symptoms and suspicious body scars indicate more than just physical illness. Sensing the teen's troubled emotional and mental state, Taub turns to the patient's personal life for clues and uncovers disturbing home videos that could put the lives of his peers in danger. Meanwhile, Cuddy remains hopeful that House will be fully present when she needs ...
A young professional champion bull rider is admitted for treatment after being attacked by a bull. After conducting multiple inconclusive tests, the team enlists House's advice outside of the hospital while he attends to a few issues away from the case. Back in the hospital, the bull rider's condition continues to worsen, but with disappearing symptoms and the patient's more frequent mini-seizures, the team's last option is risky open-heart surgery. Meanwhile, Masters develops a crush on their bull rider patient much to Taub's surprise.
A young homeless man who is a former drug addict is found in a park showing signs of olfactory impairment and horrific scars and burn marks on his chest. With an uncertain identity and the patient's severely worsening conditions, the team looks to the patient's personal records and family history in order to understand his detachment. Meanwhile, Cuddy confides in Wilson and expresses her guilt for ending her relationship with House, and just as the team warms up to the patient, they discover a disturbing secret about the man whose life they saved.
Masters faces a career crossroads on her last day as a medical student and struggles with the choice to continue on the path to become a surgeon or to accept the rare opportunity to join House's team officially. Meanwhile, the team treats a 16-year-old girl who inexplicably collapsed days before embarking on an ambitious sailing tour around the globe. Despite the patient's life-changing diagnosis, the patient's family insists on getting her back on the seas in time for her potentially record-breaking launch. But to the team's surprise, including House, Masters makes a...
Thirteen's ex-con friend, Darrien, arrives at Thirteen's apartment unannounced and in need of urgent medical attention. When she finds out that her friend has relapsed into drug use, Thirteen promises not to take her to the hospital where the cops could find her and instead turns to Chase in desperation. Meanwhile, House deals with devastating information, and Taub begins to come to terms with surprising news.
Well-known performance artist Afsoun Hamidi is admitted to the hospital, but when the team learns that her symptoms may have been self-inflicted as part of a documentary for her latest performance piece, they begin to question whether treatments are necessary and if they are unwittingly participating in the creation of a piece of her art. Meanwhile, a situation prompts House to do something that could change his relationship with Cuddy and Wilson permanently.
A year has passed since House crashed his car into Cuddy's home, and we find House spending time behind bars at the East New Jersey Correctional Facility under the close watch of the prison warden. When an antagonistic prison gang leader makes a serious threat, House solicits the help of a fellow inmate, but when another inmate's unusual medical symptoms spark his curiosity, House must come up with creative ways to treat the patient while navigating prison rules. House meets Dr. Jessica Adams, a young, intelligent and bright-eyed clinic doctor, but when they are faced...
A surprising visitor makes House an offer he can't refuse by giving him the opportunity to help the Princeton Plainsboro team treat a unique patient in order to save the life of an organ recipient being treated by Wilson. Although House finds himself back on familiar ground, he quickly realizes that much has changed since he left, and he is forced to work on the case with smart yet timid resident Dr. Chi Park. After several inconclusive treatments and with time running out, House and Dr. Park are left with one last option to examine the patient's medical history that ...
When Benjamin suddenly collapses after making a rare and generous donation, House and Dr. Chi Park are convinced that his extreme altruistic behavior may indicate a deeper medical disorder. With no definitive explanation for Benjamin's loss of consciousness and unresponsiveness to treatment, House pushes just the right buttons to recruit former prison doctor Jessica Adams to volunteer her time and expertise to the case. Benjamin then makes a bold but life-threatening offer that could save another life, and the team must diagnose his disorder before he puts his own ...
A CEO falls mysteriously ill just days before he signs a contract that would relocate his company's entire labor force to China. House attempts to make an underhanded business transaction with his wealthy patient, but when the patient's condition worsens, the team must work around the clock to save his life. Meanwhile, Park prepares for her hearing with the Princeton Plainsboro Disciplinary Committee chaired by Foreman, and Adams' outlook on her patient's business venture reveals her deeper feelings about loyalty.
A man who is well-respected in his community suddenly collapses, and in the process of diagnosing his symptoms, the team discovers that the patient has been hiding dark and dishonest secrets about his personal and professional life. But when the patient openly confesses his wrongdoings to his family and community, he compromises his chances of receiving the proper medical treatment. Meanwhile, House will stop at nothing to manipulate Taub into taking a DNA test to prove he is the father of his two six-month-old daughters.
A teenage boy attempting to follow in his late father's footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Meanwhile, House looks for creative ways to remove his ankle monitor so that he can attend a boxing match in Atlantic City, and he treats a patient who is convinced he is suffering from diabetes. Also, Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.
The team learns that their 14-year-old patient is suffering from more than teen angst when her physical symptoms worsen. Despite Foreman's firm opposition, House becomes obsessed with solving a peculiar case of a deceased four-year-old patient, which gets him into serious trouble. Meanwhile, Park tries to get Chase to admit the reason behind his recent obsession with grooming.
A prosecutor suffers from what he believes to be cardiac arrest during an interrogation at the witness stand. The team's preliminary diagnosis is hyper-anxiety, but when Adams and Park investigate the patient's home and find a hidden arsenal of firearms, they uncover a more alarming and deep-seated psychological disorder. Also, Wilson becomes obsessed with proving that House is hiding something in his home, Park slowly comes out of her social shell and Foreman's lack of romantic relationships piques the interest of Taub and Chase.
An Alzheimer's patient visits Princeton Plainsboro as part of a hospital sanctioned drug trial, but when he inexplicably suffers from violent vomiting and an increasingly explosive temper, the team begins to unravel a deeper marriage conflict between the patient and his dutiful wife. Meanwhile, House and Foreman butt heads, and Wilson treats a patient who claims to be in a chaste marriage.
The team treats an underage and homeless female patient, but when her symptoms worsen and call for an invasive surgery requiring adult consent, House and Adams argue over whether they should contact social services. The patient confesses that she ran away from home after struggling to take care of her mother, a recovering drug addict. But when her mother appears at her bedside, a more complicated relationship is revealed and the patient's mother must put the past aside and make the best decision for her daughter. Meanwhile, Taub has a difficult time connecting with ...
When a violent incident involving a patient has serious consequences for one staff member, House and the team are placed under review by Dr. Walter Cofield, Foreman's former mentor and current Chief of Neurology. As House and each member of his team recount the details of the dramatic and life-threatening incident, Cofield must weigh the team's unconventional brand of collaboration against their ability to save lives.
Chase takes on a patient, Moira, who is a cloistered nun on the verge of making her life-changing vows, and through the treatment process, he and Moira form a unique connection that tests their faith and reason. But when Moira's condition worsens and requires a risky surgery, Chase's judgment is compromised. Meanwhile, House and Taub try to remain one step ahead of each other's pranks.
A marriage counselor collapses during a speaking engagement, but when he is put under close evaluation, the team notice changes in his behavior that conflict with his motivational message on the roles of men and women. Meanwhile, House and his Ukrainian "wife" Dominika make a deal to convince Immigration that they are a happily married couple. Also, House decides to name a team leader.
House and the team battle to save a successful, independent blind man who is struck down by a mysterious illness, just prior to him asking for his girlfriend's hand in marriage. Meanwhile, House's mother unexpectedly arrives at Princeton Plainsboro to inform him of her new beau.
Das Team behandelt einen jungen Army-Veteranen, der wegen Geheimnisverrats angeklagt ist. Sein Leben gerät in Gefahr, als der Patient jegliche Behandlung verweigert, solange ihm nicht die verschlossene Akte seines verstorbenen Vaters, eines Kriegsveterans, überbracht wird. Während der junge Mann um Ehre und Leben kämpft, macht sich Adams Sorgen um die Gesundheit von House, der besorgniserregende Symptome zeigt. Trotz handfester Belege ist Chase überzeugt, dass House ein Spiel mit ihnen treibt.
Der Fall eines verletzten Eishockeyspielers, der im Lauf der Behandlung Brüste entwickelt, wird zur Knacknuss für House und sein Team. Derweil findet Wilson heraus, dass er einen elfjährigen Sohn aus einer gescheiterten Beziehung hat, von dem House offenbar gewusst hat. Die unverhoffte Begegnung mit seinem Kind verläuft verblüffend gut, doch entwickeln die Ereignisse eine beängstigende Dynamik.
House and the team take on the case of a man who starts tearing blood. Meanwhile, House is interviewing for a new favorite hooker, since his current favorite, Emily, has decided to get married and leave the business. Desperate for Emily "companionship," House teams up with his "wife" Dominika to sabotage Emily's budding relationship.
House und sein Team stossen bei der Behandlung eines achtjährigen Knaben, dessen Leben von wahrhaft mörderischen Albträumen bedroht wird, an ungewohnte Grenzen. Als sich die Befürchtungen der Familie zu bewahrheiten scheinen, dass der Patient Opfer eines familiären Fluches ist, sieht sich House gezwungen, im Kräftemessen zwischen Metaphysik und Wissenschaft nachzugeben. Derweil stürzt ihn Schein-Ehefrau Dominika in ein Wechselbad der Gefühle.
When the team takes on the case of Emily, a six-year-old girl who has numerous preexisting health problems, they must work with her mother Elizabeth, who happens to be doctor herself, specializing in her daughter's condition. The team must also deal with the battles raging between Emily's mother and father who have conflicting views on how to handle her health issues. When searching the family's home for clues to Emily's illness, the team realizes that Elizabeth's determination to cure her daughter could be the very thing that is killing her.
Ein kranker Pathologe, der sein eigenes Gehirn sezieren wollte, besteht darauf, von House persönlich behandelt zu werden. Dieser jedoch ist unterwegs mit seinem Freund Wilson, der, angesichts des drohenden Krebstodes, in die Haut eines risikofreudigen Abenteurers geschlüpft ist. Derweil bietet sich Chase mit dem komplexen Fall des Pathologen eine gute Gelegenheit, aus dem Schatten seines Meisters zu treten – Risikofreude und ein paar Lügen vorausgesetzt.
House kämpft mit „der Wut der Verzweiflung“ gegen Wilsons nahenden Tod: Vor allem die Tatsache, dass sein Freund eigenmächtig die Chemo-Behandlung abgebrochen hat, weil er sich nicht länger den damit verbundenen Schmerzen aussetzen will, macht ihm zu schaffen. Doch kein Argument kann Wilson vom Gegenteil überzeugen, was House langsam aber sicher an den Rand des Wahnsinns treibt. Ohne die Chemo bleiben Wilson nur noch sechs Monate. Doch Wilson will das Gift nicht. In seiner Ohnmacht macht House Dinge, die weit über das Erlaubte gehen. Als er erfährt, dass ein junger Patient sich umbringen wollte, geht er zu ihm und würgt ihn. Nur mit Mühe kann sein Team ihn davon abbringen, den Jungen zu ermorden. Er sabotiert die Abflussrohre, so dass sich schließlich ein Schwall von Abwassern, über dem MRT ergießt und damit einen gewaltigen Schaden verursacht. Erst, als Wilson beschließt, die Chemo doch weiterzumachen, findet er wieder zu sich. Beide planen, in der noch bleibenden Zeit, eine Kurzreise in die Berge zu machen. Doch es kommt anders: Foreman taucht in Begleitung eines Anwaltes auf und verkündet House, dass er – aufgrund der Beschädigung des MRTs – wieder ins Gefängnis muss, und zwar für genau sechs Monate.
House überlegt intensiv, wie er verhindern kann, dass er vor Wilsons Tod ins Gefängnis muss. Zuerst überredet er Foreman zu einer Falschaussage. Doch als diesem die Sache zu heiß wird, macht Foreman einen Rückzieher. Dann versucht er sein Glück bei Wilson, aber auch der hat keine Lust auf einen Meineid. Doch zufällig bekommt House einen neuen Patienten, der ebenfalls dem Tod geweiht ist. Der erklärt sich bereit, House zu helfen – allerdings nur unter bestimmten Bedingungen. Der unberechenbare Arzt soll den Mann auf seinem letzten Weg begleiten. Das Ganze soll in einem Lagerhaus passieren. Der passenden Atmosphäre geschuldet, brennt bei Houses Ankunft bereits ein Feuer, das jedoch langsam auf das ganze Lagerhaus übergreift. In der Zwischenzeit sind Foreman und Wilson auf der Suche nach House – beide vermuten Schlimmes. Während House sich der tödlichen Lage ergibt, erscheinen ihm einige Personen, die ihn auf seinem Weg durch das Princeton Plainsboro begleitet haben. Aber keiner der geisterhaften Erscheinungen kann ihn dazu überreden, das brennende Haus zu verlassen. In der Zwischenzeit haben Foreman und Wilson endlich Houses Aufenthaltsort herausgefunden. Als sie ihn in dem Gebäude entdecken, sehen sie wie die brennende Decke über House zusammenstürzt. Doch ist House tatsächlich tot?